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KMID : 0620920070390030395
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Experimental & Molecular Medicine
2007 Volume.39 No. 3 p.395 ~ p.401
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Exercise type and muscle fiber specific induction of caveolin-1 expression for insulin sensitivity of skeletal muscle
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Oh Yoon-Sin
Kim Hyo-Jeong
Ryu Sung-Jin
Cho Kyung-A
Park Young-Sik
Park Hyun
Kim Mi-Jeong
Kim Chang-Keun
Park Sang-Chul
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Abstract
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It is well known that exercise can have beneficial effects on insulin resistance by activation of glucose transporter. Following up our previous report that caveolin-1 plays an important role in glucose uptake in L6 skeletal muscle cells, we examined whether exercise alters the expression of caveolin-1, and whether exercise-caused changes are muscle fiber and exercise type specific. Fifity week-old Sprague Dawley (SD) rats were trained to climb a ladder and treadmill for 8 weeks and their soleus muscles (SOL) and extensor digitorum longus muscles (EDL) were removed after the last bout of exercise and compared with those from non-exercised animals. We found that the expression of insulin related proteins and caveolins did not change in SOL muscles after exercise. However, in EDL muscles, the expression of insulin receptor b (IRb) and glucose transporter-4 (GLUT-4) as well as phosphorylation of AKT and AMPK increased with resistance exercise but not with aerobic exercise. Also, caveolin-1 and caveolin-3 increased along with insulin related proteins only in EDL muscles by resistance exercise. These results suggest that upregulation of caveolin-1 in the skeletal muscle is fiber specific and exercise type specific, implicating the requirement of the specific mode of exercise to improve insulin sensitivity.
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KEYWORD
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caveolin 1, exercise therapy, glucose transporter type 4, muscle, skeletal, receptor, insulin
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